سازگاری مقادیر سرمی آیریزین، پروفایل لیپیدی و مقاومت به انسولین به یک دوره تمرین هوازی و مصرف خوراکی سرگل زعفران و نیز ماندگاری پس از آن در زنان چاق دیابتی نوع 2

Background and Objective: In order to study the beneficial role of aerobic activities and consumption of saffron which has various biological properties, the adaptability of serum irisin, lipid profiles and insulin resistance to an aerobic training and consumption of saffron sprouts as well as its sustainability in type 2 diabetic obese women was closely examined. &nbsp; Materials and Methods: Forty-eight type 2 diabetic obese women were randomly divided into four equal groups (saffron + training, training + placebo, saffron, placebo). The saffron group + training and training + placebo groups did aerobic training with an intensity of 60-75% of maximal heart rate for 8 weeks (three sessions per week). A daily dose of 400 mg of saffron sprout powder (once a day) was used for two months. The placebo contained 400 mg of wheat flour. Then, the variables of irisin, lipid profiles, and HOMA-IR were investigated. &nbsp; Results: The results of this study showed that there were significant differences between training + saffron group and training + placebo, training + saffron and saffron, training + saffron and placebo, training + placebo and placebo, and saffron and placebo (P<0.05) in the post-test regarding TC, TG, LDL-C, HOMA-IR, and body fat percent (a decrease in experimental group and non-significant changes in control group), HDL-C and irisin (an increase in experimental groups and non-significant changes in control group). In addition, there were significant differences between group training + saffron (decrease) and placebo, training + placebo (decrease) and placebo, and saffron (decrease) and placebo (no significant increase), (p<0.05) with regard to weight and BMI variables. There were also significant differences between training + saffron (decrease) group and placebo (no significant decrease) (p<0.0001) and training + placebo (decrease) and placebo (no significant decrease) (p<0.01). &nbsp; Conclusion: Eight weeks of aerobic training and saffron consumption have a significant effect on the indices related to type 2 diabetes. It needs to be mentioned that the consumption of saffron along with aerobic exercise has more effects on controlling these indices.